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陈洁

2020-04-09  来源:


  

陈洁

性别

出生年份

1977年7月

职称

副教授/硕士生导师

固定电话

0531-88382134

E-mail

77chenjie@sdu.edu.cn


个人简介


陈洁,博士,副教授,妇幼保健专业硕士生导师,现任儿少卫生与妇幼保健学系副主任。近年来承担国家级课题2项,省部级课题4项。以第一作者或通讯作者在国内外发表论文10余篇,其中SCI收录10余篇。主要从事妇科肿瘤防治以及孕产妇遗传咨询、产前诊断、生殖内分泌疾病的研究。

教育经历


2015.08-2016.08  斯坦福大学,访问学者

2014.07-2016.09  山东大学,博士后,公共卫生与预防医学

2000.09-2005.07  山东大学,博士,妇产科

1995.09-2000.07  山东大学,本科,临床医学

工作经历


2013.07至今 新葡的京集团app    副教授/硕士生导师

2005.07-2013.07 新葡的京集团app    讲师

研究领域


1.妇科肿瘤防治,肿瘤分子标志物鉴定与早期筛查,恶性肿瘤发生转移的分子监测及机制研究。

2.孕产妇遗传咨询、产前诊断、生殖内分泌疾病的研究。

承担的主要研究课题


1、横向课题,1320019009,女性产后盆底功能缺陷的综合性康复研究,2019.10-2022.10,在研,主持

2、山东省重点研发计划,2018GSF118049,EFEMP1-STEAP1受体系统在卵巢癌发生发展及防治中作用的研究,2018.01-2019.12,15万,已结题,主持

3、山东省自然科学基金,ZR2017MH060,STEAP1在卵巢癌发生发展和血管生成中作用机制的研究,2017/08-2020/06,13万,结题,主持

4、中国博士后科学基金,2014M551919,fibulin-4在卵巢癌发生发展中作用机制的研究,2014/06-2016/06,5万元,已结题,主持

5、国家自然基金青年科学基金,81202056,EFEMP1对卵巢癌细胞侵袭转移和血管生成作用的研究,2013/01-2015/12,23万元,已结题,主持

7、山东大学自主创新基金,2012TS088,HMGB1促进卵巢癌细胞侵袭转移分子机制的研究,2012/01-2014/12,7万元,已结题,主持

7、山东省优秀中青年科学家科研奖励基金,2007BS03025,轴突导向分子Semaphorins及其受体与卵巢癌转移关系的研究,2007/01-2009/12,6万元,已结题,主持

主要学术论文


1. Chen J, Zhang J, Zhao Y, Li J, Fu M. Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol. 2009; 135(7): 909-917.

2. Chen J, Wang M, Xi B, Xue J, He D, Zhang J, Zhao Y. SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. PLoS One. 2012;7(8):e42413. Epub 2012 Aug 3.

3. Chen J, Shi D, Liu X, Fang S, Zhang J, Zhao Y. Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 2012 Oct 10;12(1):464.

4. Chen J, Wei D, Zhao Y, Liu X, Zhang J. Overexpression of EFEMP1 Correlates with Tumor Progression and Poor Prognosis in Human Ovarian Carcinoma. PLoS One. 2013 Nov 13;8(11):e78783.

5. Chen J, Zhang J, Liu X, Fang R, Zhao Y, Ma D. Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep. 2014 Jun;31(6):2601-10.

6. Chen J, Liu Z, Fang S, Fang R, Liu X, Zhao Y, Li X, Huang L, Zhang J. Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas. BMC Cancer. 2015 Mar 4;15:91.

窗体顶端

窗体底端

7. Yin X, Fang S, Wang M, Wang Q, Fang R, Chen J (Corresponding author). EFEMP1 promotes ovarian cancer cell growth, invasion and metastasis via activated the AKT pathway. Oncotarget. 2016 Jul 26;7(30):47938-47953.

窗体底端

8.Wang T, Wang M, Fang S, Wang Q, Fang R, Chen J (Corresponding author). Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway. Oncotarget. 2017 Mar 21;8(12):18991-19012.

9. Xie J, Yang Y, Sun J, Jiao Z, Zhang H, Chen J (Corresponding author). STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession. Clin Breast Cancer. 2019 Feb;19(1):e195-e207.

10. Sun J, Ji G, Xie J, Jiao Z, Zhang H, Chen J (Corresponding author). Six-transmembrane epithelial antigen of the prostate 1 is associated with tumor invasion and migration in endometrial carcinomas. J Cell Biochem. 2019 Feb 3. doi: 10.1002/jcb.28393.

11. Jiao Z, Huang L, Sun J, Xie J, Wang T, Yin X, Zhang H, Chen J (Corresponding author). Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition. Histochem Cell Biol. 2020 May 7. doi: 10.1007/s00418-020-01877-7.

12. Jin X, Liu G, Jiao Z, Sun J, Yan M, Lv X, Zhang H, Chen J (Corresponding author). Pregnancy Outcome Difference between Fresh and Frozen Embryos in Women without Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis. Reprod Sci. 2020 Oct 1. doi: 10.1007/s43032-020-00323-2.


Curriculum Vitae

Family name:           Chen    

First names:               Jie   

Year of birth:        July 24, 1977

Gender:                 Female

Working institution: Department of Social medicine and Maternal & Child Health, School of Public Health, Shandong University

Working experiences /Present position:        Associate Professor

          2013-to date        Associate Professor, School of Public Health, Shandong University

            2005-2013      Lecturer, School of Public Health, Shandong University

Education:     

Institution

(Date from - Date to)

Degree(s) or Diploma(s) obtained:

Stanford University, USA

(2015.08-2016.08)

Visiting scholar, OBGYN

Shandong University, P.R. China

(2000.09-2005.07)

Ph.D (direct PhD program), School of Medicine

Shandong University, P.R. China

(1995.09-2000.07)

M.B., School of Medicine


Expertise/Research issues:

1.Study on genetic counseling, prenatal diagnosis and reproductive endocrine diseases in pregnant women.

2.Molecular identification and early screening of tumor markers; mechanism of carcinogenesis and metastasis of malignant maternal tumors.


Selected Research Projects as PIs:

1.Study on the role of EFEMP1-STEAP1 ligand receptor complex in the occurrence, development, prevention and treatment of ovarian cancer

Agency: Key R&D plan of Shandong Province

Funding period: August 1, 2018- June 30, 2019

2.Study on the mechanism of STEAP1 in carcinogenesis, development and angiogenesis of ovarian cancer

Agency: Shandong Natural Science Foundation of China

Funding period: August 1, 2017- June 30, 2020

3.The research about the role of EFEMP1 in ovarian cancer invasion, metastasis and angiogenesis

Agency: National Nature Science Foundation of China

Funding period: January 1, 2013- December 30, 2015

4.The role of fibulin-4 in the pathogenesis and development of ovarian cancer

Agency: China Postdoctoral Science Foundation

Funding period: January 1, 2013- December 30, 2014


Selected Publications

1.Chen J, Zhang J, Zhao Y, Li J, Fu M. Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones. J Cancer Res Clin Oncol. 2009; 135(7): 909-917.

2.Chen J, Wang M, Xi B, Xue J, He D, Zhang J, Zhao Y. SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. PLoS One. 2012;7(8):e42413. Epub 2012 Aug 3.

3.Chen J, Shi D, Liu X, Fang S, Zhang J, Zhao Y. Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 2012 Oct 10;12(1):464.

4.Chen J, Wei D, Zhao Y, Liu X, Zhang J. Overexpression of EFEMP1 Correlates with Tumor Progression and Poor Prognosis in Human Ovarian Carcinoma. PLoS One. 2013 Nov 13;8(11):e78783.

5. Chen J, Zhang J, Liu X, Fang R, Zhao Y, Ma D. Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep. 2014 Jun;31(6):2601-10.

6. Chen J, Liu Z, Fang S, Fang R, Liu X, Zhao Y, Li X, Huang L, Zhang J. Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas. BMC Cancer. 2015 Mar 4;15:91.

7. Yin X, Fang S, Wang M, Wang Q, Fang R, Chen J (Corresponding author). EFEMP1 promotes ovarian cancer cell growth, invasion and metastasis via activated the AKT pathway. Oncotarget. 2016 Jul 26;7(30):47938-47953.

窗体底端

8.Wang T, Wang M, Fang S, Wang Q, Fang R, Chen J (Corresponding author). Fibulin-4 is associated with prognosis of endometrial cancer patients and inhibits cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway. Oncotarget.  2017 Mar 21;8(12):18991-19012.

9.Xie J, Yang Y, Sun J, Jiao Z, Zhang H, Chen J (Corresponding author). STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession. Clin Breast Cancer. 2019 Feb;19(1):e195-e207.

10.Sun J, Ji G, Xie J, Jiao Z, Zhang H, Chen J (Corresponding author). Six-transmembrane epithelial antigen of the prostate 1 is associated with tumor invasion and migration in endometrial carcinomas. J Cell Biochem. 2019 Feb 3. doi: 10.1002/jcb.28393.

11. Jiao Z, Huang L, Sun J, Xie J, Wang T, Yin X, Zhang H, Chen J (Corresponding author). Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition. Histochem Cell Biol. 2020 May 7. doi: 10.1007/s00418-020-01877-7.

12. Jin X, Liu G, Jiao Z, Sun J, Yan M, Lv X, Zhang H, Chen J (Corresponding author). Pregnancy Outcome Difference between Fresh and Frozen Embryos in Women without Polycystic Ovary Syndrome: a Systematic Review and Meta-Analysis. Reprod Sci. 2020 Oct 1. doi: 10.1007/s43032-020-00323-2.



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